The Town of Hillsborough was established in 1754, two years after the formation of Orange County, where the Great Indian Trading Path crossed the Eno River.For many years Hillsborough was a leading town in its region of North Carolina and many significant historical events occurred here. There remain more than 100 late eighteenth and nineteenth-century structures that illustrate this history. In addition, there are numerous secondary buildings, bridges, mill sites, and dams along with the Eno, and Native American relics from the locations of ancient towns stretching back thousands of years.